Emmanuel Eric Pazo

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The Effects of Repeated Low-Level Red-Light Therapy on the Structure and Vasculature of the Choroid and Retina in Children with Premyopia

Zhuzhu Liu, Ziwen Sun, Bei Du, Huaixue Gou, Biying Wang, Zeya Lin, Nuo Ren, Emmanuel Eric Pazo, Lin Liu, Ruihua Wei

Ophthalmology and Therapy, 2024 · article · doi:10.1007/s40123-023-00875-x · cited by 61 · Open access (CC BY-NC)

Retina & vascular imagingMyopia & refractive error

Abstract

INTRODUCTION: The purpose of this study was to explore the effects of repeated low-level red-light (RLRL) therapy on the structure and vasculature of the choroid and retina in Chinese children with premyopia. METHODS: This study was a single-center randomized clinical trial. A total of 94 children with premyopia (- 0.50 D < spherical equivalent [SE] ≤ + 0.75 D) were randomly assigned to either the RLRL therapy or control group. Follow-up visits were planned at 1, 3, 6, 9, and 12 months. Optical coherence biometry was used to measure axial length (AL) and anterior segment parameters. Choroidal thickness (CT), retinal thickness (RT), superficial retinal vascular density (SRVD), deep retinal vascular density (DRVD), choriocapillaris perfusion area (CCPA), and choroidal vessel volume (CVV) were measured by optical coherence tomography angiography, centered on the foveal, parafoveal (ParaF), and perifoveal (PeriF) regions. RESULTS: ) (all P < 0.05). In addition, no notable differences were observed between the groups regarding foveal RT and retinal vascular parameters throughout the 12 months (P > 0.05). Notably, RLRL therapy achieved a notable reduction in SE shift by 73.8%, a substantial decrease in AL change by 67.9%, and a significant reduction in myopia incidence by 45.1% within 1 year. CONCLUSION: Our study demonstrated a significant increase in CT and flow in the RLRL-treated eyes throughout the 12-months of the study. Combined with its reduction in spherical equivalent progression and axial elongation, RLRL could be used as an effective therapy for preventing progression in premyopes. TRIAL REGISTRATION: ChiCTR2200062028.

Keywords: low-level red light therapy; low-level laser therapy; myopia progression prevention; choroidal thickness; retinal thickness; retinal vessel density; axial length; spherical equivalent

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How to cite

Liu, Z., Sun, Z., Du, B., Gou, H., Wang, B., Lin, Z., Ren, N., Pazo, E. E., Liu, L., Wei, R. (2024). The Effects of Repeated Low-Level Red-Light Therapy on the Structure and Vasculature of the Choroid and Retina in Children with Premyopia. Ophthalmology and Therapy. https://doi.org/10.1007/s40123-023-00875-x

@article{liu2024the,
  title = {{The Effects of Repeated Low-Level Red-Light Therapy on the Structure and Vasculature of the Choroid and Retina in Children with Premyopia}},
  author = {Liu, Zhuzhu and Sun, Ziwen and Du, Bei and Gou, Huaixue and Wang, Biying and Lin, Zeya and Ren, Nuo and Pazo, Emmanuel Eric and Liu, Lin and Wei, Ruihua},
  journal = {Ophthalmology and Therapy},
  year = {2024},
  doi = {10.1007/s40123-023-00875-x},
  url = {https://doi.org/10.1007/s40123-023-00875-x},
}

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