Emmanuel Eric Pazo

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Effects of corneal epithelial remodeling on corneal asphericity after FS-LASIK and Trans-PRK: A prospective study

Mingyu Xu, Fan Yang, Emmanuel Eric Pazo, Qiwei Li, Zheng Kun Yang, Yue Huang, Shaozhen Zhao

Indian Journal of Ophthalmology, 2024 · article · doi:10.4103/ijo.ijo_623_24 · cited by 10 · Open access (CC BY-NC-SA)

Cataract & anterior segment surgeryOcular surface & dry eye

Abstract

PURPOSE: To observe the changes in corneal epithelial thickness after FS-LASIK and Trans-PRK surgery and to investigate the impact of corneal epithelial remodeling on Q-value and HOA. METHODS: In this prospective cohort study, 50 patients (100 eyes) underwent FS-LASIK and 45 patients (90 eyes) underwent Trans-PRK. Anterior segment OCT was used to measure the corneal epithelial thickness in different corneal zones (central zone: 0-2 mm; paracentral zone: 2-5 mm; and mid-peripheral zone: 5-6 mm) preoperatively and postoperatively at 1 week, 1 month, 3 months, and 6 months. The correlation between △CET in the superior, nasal, inferior, and temporal region at 6 months postoperatively and △Q and △HOA was analyzed. RESULTS: At 6 months postoperatively, the epithelial thickness increased in the central, paracentral, and mid-peripheral zones in FS-LASIK and Trans-PRK. Central epithelial thickness and different regions of the paracentral zone and mid-peripheral exhibited significant thickening ( P < 0.001). In the para-central zone and mid-peripheral zone, the △CET in different regions after LASIK and Trans-PRK was positively correlated with △Q ( P < 0.05) and △HOA ( P < 0.05). CONCLUSION: After FS-LASIK and Trans-PRK, significant epithelial thickening was observed. Epithelial changes in different regions lead to different Q-values in different regions and have different effects on HOA. This has a certain guiding significance for the design of refractive surgery, and minimizing the increase of Q-value may improve the postoperative visual quality.

Keywords: corneal epithelial thickness; FS-LASIK; corneal asphericity; Q-value; higher-order aberrations; refractive surgery; postoperative visual quality; anterior segment OCT

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How to cite

Xu, M., Yang, F., Pazo, E. E., Li, Q., Yang, Z. K., Huang, Y., Zhao, S. (2024). Effects of corneal epithelial remodeling on corneal asphericity after FS-LASIK and Trans-PRK: A prospective study. Indian Journal of Ophthalmology. https://doi.org/10.4103/ijo.ijo_623_24

@article{xu2024effects,
  title = {{Effects of corneal epithelial remodeling on corneal asphericity after FS-LASIK and Trans-PRK: A prospective study}},
  author = {Xu, Mingyu and Yang, Fan and Pazo, Emmanuel Eric and Li, Qiwei and Yang, Zheng Kun and Huang, Yue and Zhao, Shaozhen},
  journal = {Indian Journal of Ophthalmology},
  year = {2024},
  doi = {10.4103/ijo.ijo_623_24},
  url = {https://doi.org/10.4103/ijo.ijo_623_24},
}

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