Emmanuel Eric Pazo

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Comparison of non-pharmaceutical treatments for evaporative dry eye: a randomised controlled study protocol

Jiayan Chen, Guanghao Qin, Sile Yu, Jonathan Edward Moore, Ling Xu, Wei He, Emmanuel Eric Pazo, Xingru He

BMJ Open, 2024 · article · doi:10.1136/bmjopen-2023-078727 · cited by 3 · Open access (CC BY-NC)

Ocular surface & dry eye

Abstract

INTRODUCTION: The lipid layer of the tear film is critical to maintaining the integrity of the tear film and absence in the tear film lipid layer (TFLL) is one of the main causes of evaporative dry eye (EDE) in dry eye disease patients, resulting in excessive evaporation (so-called hyperevaporative dry eye). This study protocol will be designed to assess and compare the effects of intense pulsed light (IPL), heated eye mask (HEM), vectored thermal pulsation system (VTPS) and eyelid massage device (EMD) for improving signs and symptoms of EDE. METHODS AND ANALYSIS: Patients with EDE will be randomly divided into IPL, HEM, VTPS and EMD groups and will be followed up for 6 weeks. The primary outcome measure will be non-invasive tear breakup time (NITBUT). The secondary outcome measures will include, TFLL score, meibomian gland quality and expressibility change from baseline conjunctivocorneal staining with fluorescein and lissamine, tear meniscus height, conjunctival hyperaemia (redness score) and ocular surface disease index questionnaire. Additionally, adverse events will be monitored and documented. ETHICS AND DISSEMINATION: Ethics approval number: IRB(2023)K019.01. The findings will be shared regardless of the effect's direction. TRIAL REGISTRATION NUMBER: NCT05923528.

Keywords: evaporative dry eye; non-pharmacological treatment; intense pulsed light; tear film lipid layer; meibomian gland dysfunction; tear meniscus height; conjunctival hyperemia; ocular surface disease

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How to cite

Chen, J., Qin, G., Yu, S., Moore, J. E., Xu, L., He, W., Pazo, E. E., He, X. (2024). Comparison of non-pharmaceutical treatments for evaporative dry eye: a randomised controlled study protocol. BMJ Open. https://doi.org/10.1136/bmjopen-2023-078727

@article{chen2024comparison,
  title = {{Comparison of non-pharmaceutical treatments for evaporative dry eye: a randomised controlled study protocol}},
  author = {Chen, Jiayan and Qin, Guanghao and Yu, Sile and Moore, Jonathan Edward and Xu, Ling and He, Wei and Pazo, Emmanuel Eric and He, Xingru},
  journal = {BMJ Open},
  year = {2024},
  doi = {10.1136/bmjopen-2023-078727},
  url = {https://doi.org/10.1136/bmjopen-2023-078727},
}

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