Emmanuel Eric Pazo

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Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy

Guanghao Qin, Jiayan Chen, Liangzhe Li, Xia Yang, Qing Zhang, Yi Wu, Lanting Yang, Salissou Moutari, Jonathan Edward Moore, Ling Xu, Wei He, Sile Yu, Xingru He, Emmanuel Eric Pazo

Ophthalmology and Therapy, 2023 · article · doi:10.1007/s40123-023-00649-5 · cited by 22 · Open access (CC BY-NC)

Ocular surface & dry eye

Abstract

INTRODUCTION: This study assessed the efficacy and safety of intense pulsed light (IPL) therapy in participants with severe evaporative dry eye disease (DED). METHODS: This randomized, controlled, single-center study included 49 adult participants (≥ 18 years) with severe evaporative DED who received either IPL therapy (n = 56 eyes) or sham therapy (n = 42 eyes) three times. The primary efficacy parameters were ocular surface disease index (OSDI) score, non-invasive tear breakup time (NITBUT), tear film lipid layer (TFLL), conjunctivocorneal staining score (CS), MG Score, meibomian gland (MG) quality, and MG expression score. RESULTS: The mean ages for the IPL group and the control group were 28.05 ± 3.41 years (57.1% female) and 28.14 ± 3.53 years (52.4% female), respectively. Comparison between the IPL group and the control group found significant differences in the mean OSDI score (22.16 ± 6.08 vs. 42.38 ± 6.60; P < 00.01), NITBUT (6.27 ± 0.84 vs. 3.86 ± 0.68; P < 0.001), TFLL (2.14 ± 0.44 vs. 3.45 ± 0.50; P < 0.001), MG Score (1.34 ± 0.55 vs. 1.88 ± 0.33; P < 0.001), MG quality (1.59 ± 0.07 vs. 2.67 ± 0.08), and MG expression (1.54 ± 0.57 vs. 2.45 ± 0.55) at 12 weeks follow-up; however, there was no significant difference in CS (3.32 ± 1.11 vs. 3.74 ± 1.04; P = 0.063). CONCLUSION: The findings suggest that IPL therapy is clinically beneficial in ameliorating the signs and symptoms of severe evaporative dry eye disease.

Keywords: evaporative dry eye disease; intense pulsed light therapy; meibomian glands; meibography; tear film lipid layer; Ocular Surface Disease Index; treatment efficacy and safety

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How to cite

Qin, G., Chen, J., Li, L., Yang, X., Zhang, Q., Wu, Y., Yang, L., Moutari, S., Moore, J. E., Xu, L., He, W., Yu, S., He, X., Pazo, E. E. (2023). Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy. Ophthalmology and Therapy. https://doi.org/10.1007/s40123-023-00649-5

@article{qin2023managing,
  title = {{Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy}},
  author = {Qin, Guanghao and Chen, Jiayan and Li, Liangzhe and Yang, Xia and Zhang, Qing and Wu, Yi and Yang, Lanting and Moutari, Salissou and Moore, Jonathan Edward and Xu, Ling and He, Wei and Yu, Sile and He, Xingru and Pazo, Emmanuel Eric},
  journal = {Ophthalmology and Therapy},
  year = {2023},
  doi = {10.1007/s40123-023-00649-5},
  url = {https://doi.org/10.1007/s40123-023-00649-5},
}

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