Emmanuel Eric Pazo

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Effect of Intense Pulsed Light on Anterior Corneal Aberrations and Quality of Vision in Patients with Evaporative Dry Eye

Lanting Yang, Emmanuel Eric Pazo, Guanghao Qin, Zhang Qing, Yi Wu, Yilin Song, Hongda Zhang, Tiezhu Lin, Ling Xu, Jonathan Edward Moore, Wei He

Photobiomodulation Photomedicine and Laser Surgery, 2021 · article · doi:10.1089/photob.2020.4953 · cited by 16

Ocular surface & dry eye

Abstract

Objective: To evaluate the improvement in the tear film lipid layer (TFLL) and its subsequent impact upon corneal aberrations following intense pulsed light (IPL) treatment in patients with evaporative dry eye disease (DED) due to meibomian gland dysfunction (MGD). Background: The prevalence of DED is common and can lead to ocular discomfort, reduced visual acuity, and lowered quality of vision (QoV) and life. Methods: In this self-control study, patients with moderate-to-severe evaporative DED due to MGD were consecutively enrolled and underwent two IPL treatments at 3-week intervals. Clinical assessments, such as Ocular Surface Disease Index (OSDI) and QoV questionnaires, anterior corneal aberrations, noninvasive tear breakup time (NITBUT), interferometric fringe pattern as determined by TFLL quality, corneal fluorescein staining (CFS), meibum gland (MG), conjunctival hyperemia (CH), best-corrected visual acuity, endothelial cell count, and intraocular pressure, were conducted at pretreatment (D-0), day 21 (D-21), and day 42 (D-42) after IPL treatment. Results: The final analysis included 124 eyes of 62 patients (29 females, 33 males; mean age 35.66 ± 11.09 years). Clinically and statistically significant improvement in NITBUT was observed at D-42 ( p < 0.01). OSDI, QoV, TFLL score, and MG quality and expressibility all improved significantly ( p < 0.05) at D-42, whereas CH ( p = 0.073) and CFS ( p = 0.058) showed minor not significant improvements at D-42 of assessment. Anterior corneal aberrations also improved significantly at D-42 of assessment ( p < 0.05). Conclusions: IPL treatment reduced the severity of symptoms and improved the overall tear film (TF) stability in patients with moderate-to-severe evaporative dry eye (DE) due to MGD. Additionally, the significant improvement in QoV in DE patients can be attributed to the reduction in anterior corneal aberrations due to improved TF stability.

Keywords: intense pulsed light; evaporative dry eye; meibomian gland dysfunction; tear film lipid layer; visual quality; conjunctival hyperemia; corneal fluorescein staining; Ocular Surface Disease Index

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How to cite

Yang, L., Pazo, E. E., Qin, G., Qing, Z., Wu, Y., Song, Y., Zhang, H., Lin, T., Xu, L., Moore, J. E., He, W. (2021). Effect of Intense Pulsed Light on Anterior Corneal Aberrations and Quality of Vision in Patients with Evaporative Dry Eye. Photobiomodulation Photomedicine and Laser Surgery. https://doi.org/10.1089/photob.2020.4953

@article{yang2021effect,
  title = {{Effect of Intense Pulsed Light on Anterior Corneal Aberrations and Quality of Vision in Patients with Evaporative Dry Eye}},
  author = {Yang, Lanting and Pazo, Emmanuel Eric and Qin, Guanghao and Qing, Zhang and Wu, Yi and Song, Yilin and Zhang, Hongda and Lin, Tiezhu and Xu, Ling and Moore, Jonathan Edward and He, Wei},
  journal = {Photobiomodulation Photomedicine and Laser Surgery},
  year = {2021},
  doi = {10.1089/photob.2020.4953},
  url = {https://doi.org/10.1089/photob.2020.4953},
}

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