Emmanuel Eric Pazo

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Corneal Nerves Alteration Associated with Corneal Complications after Pars Plana Vitrectomy

Tiezhu Lin, Hong Ye, Emmanuel Eric Pazo, Guangzheng Dai, Yang Xia, Wei He

Korean Journal of Ophthalmology, 2021 · article · doi:10.3341/kjo.2021.0048 · cited by 3 · Open access (CC BY-NC)

Ocular surface & dry eye

Abstract

PURPOSE: To evaluate the effect of corneal nerves assessment on predicting corneal complications following pars plana vitrectomy (PPV). METHODS: In this prospective single-center cohort study, 94 patients (94 eyes) received PPV, and were divided into postoperative groups with and without corneal complications. All eyes had corneal nerve fiber length (CNFL), corneal nerve fiber density, and branch density of corneal nerve fibers assessed and calculated with Image J preoperatively. Multivariate logistic regression analysis was used to identify corneal nerve fiber parameters that correlated to post-operative corneal complications. Receiver operator characteristic curve analysis was performed to identify the optimal cut-off point of the corneal fibers' parameters for predicting corneal complications after PPV. RESULTS: Eleven eyes (11.70%) developed corneal complications at 1 week after PPV. There was significant difference between CNFL (19.44 ± 6.88 vs. 26.84 ± 7.53, p = 0.003), corneal nerve fiber density (28.82 ± 9.91 vs. 37.10 ± 10.16, p = 0.013) and branch density of corneal nerve fibers (55.84 ± 21.08 vs. 82.04 ± 31.89, p = 0.01) in two groups, respectively. Receiver operator characteristic analysis showed that the optimal cutoff value of CNFL to predict corneal complications following PPV was <26.495 mm/mm2. CONCLUSIONS: The decrease of CNFL may predict corneal complications following PPV. Regular preoperative corneal confocal microscopy test in PPV patients could be considered.

Keywords: pars plana vitrectomy; corneal complications; corneal nerve fiber length; corneal nerve fiber density; corneal nerve branch density; corneal confocal microscopy; postoperative outcome prediction; diabetic retinopathy

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How to cite

Lin, T., Ye, H., Pazo, E. E., Dai, G., Xia, Y., He, W. (2021). Corneal Nerves Alteration Associated with Corneal Complications after Pars Plana Vitrectomy. Korean Journal of Ophthalmology. https://doi.org/10.3341/kjo.2021.0048

@article{lin2021corneal,
  title = {{Corneal Nerves Alteration Associated with Corneal Complications after Pars Plana Vitrectomy}},
  author = {Lin, Tiezhu and Ye, Hong and Pazo, Emmanuel Eric and Dai, Guangzheng and Xia, Yang and He, Wei},
  journal = {Korean Journal of Ophthalmology},
  year = {2021},
  doi = {10.3341/kjo.2021.0048},
  url = {https://doi.org/10.3341/kjo.2021.0048},
}

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